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Category: Ketamine therapy

Spravato (esketamine) explained: how it works in the brain

Why Spravato (esketamine) acts in 24 hours when SSRIs take six to eight weeks — and why the dissociation patients fear is not the antidepressant. A patient-first walkthrough of the NMDA → AMPA → BDNF

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How Treatment-Resistant Depression Is Diagnosed: The Two-Failed-Trials Standard, Explained

A patient-facing clinical guide to the FDA/EMA two-failed-trials standard for diagnosing treatment-resistant depression — what counts as an adequate trial, why pseudoresistance must be ruled out first, and what comes next. By Nefretiri Abat, PMHNP-BC,

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What Is Treatment-Resistant Depression? A Clinician’s Guide to TRD

A 2026 clinical guide to treatment-resistant depression: definitions, pseudoresistance workup, evidence-based treatments including SPRAVATO monotherapy, SAINT, and a 10-step management algorithm. By Nefretiri Abat, PMHNP-BC, JD.

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Find Relief Where You Are – Healing Starts at Exxceed Wellness

If depression, anxiety, PTSD, or persistent burnout has been weighing you down—making even the basics feel overwhelming—we see you. You’re not alone, and these challenges are real. At Exxceed Wellness, we’re opening in Castro Valley

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