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Day: May 10, 2026

Sunlit writing desk with leather-bound notebook, fountain pen, and coffee — symbolizing the careful medication audit that defines a real treatment-resistant depression diagnosis. Exxceed Wellness, Hayward CA.
Ketamine therapy

How Treatment-Resistant Depression Is Diagnosed: The Two-Failed-Trials Standard, Explained

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A patient-facing clinical guide to the FDA/EMA two-failed-trials standard for diagnosing treatment-resistant depression — what counts as an adequate trial, why pseudoresistance must be ruled out first, and what comes next. By Nefretiri Abat, PMHNP-BC,

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