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Category: TMS therapy

TMS vs. Medication for Treatment-Resistant Depression: How to Tell Which Path Fits You Next

After two failed antidepressants, the real question is rarely TMS or medication — it is which pathway has not been tried yet, which side effects you can tolerate, and which treatment you can actually finish.

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What If Neither SPRAVATO Nor TMS Works for Me?

If you have completed both SPRAVATO and TMS without the response you needed, you are not at the end of psychiatry. A patient guide to the evidence-based options that come next.

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Is Spravato or TMS Better for Treatment-Resistant Depression? A Patient’s Decision Guide

You've tried two antidepressants. Now your psychiatrist is talking about Spravato — or TMS. A specialist breaks down both, with the numbers and the realities.

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Spravato vs. Ketamine Infusions for TRD: What’s the Difference — and Why We Chose Spravato

Both Spravato (esketamine) and IV ketamine work fast for treatment-resistant depression. Here's how they differ in FDA approval, safety oversight, insurance coverage, and clinical evidence — and why our practice offers Spravato. By Nefretiri Abat,

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Can I Do SPRAVATO and TMS at the Same Time? A Treatment-Resistant Depression Specialist Answers

For most patients with TRD, SPRAVATO and TMS can be combined or sequenced. Here's what the evidence says — and how we sequence at Exxceed Wellness.

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Spravato (esketamine) explained: how it works in the brain

Why Spravato (esketamine) acts in 24 hours when SSRIs take six to eight weeks — and why the dissociation patients fear is not the antidepressant. A patient-first walkthrough of the NMDA → AMPA → BDNF

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How Treatment-Resistant Depression Is Diagnosed: The Two-Failed-Trials Standard, Explained

A patient-facing clinical guide to the FDA/EMA two-failed-trials standard for diagnosing treatment-resistant depression — what counts as an adequate trial, why pseudoresistance must be ruled out first, and what comes next. By Nefretiri Abat, PMHNP-BC,

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What Is Treatment-Resistant Depression? A Clinician’s Guide to TRD

A 2026 clinical guide to treatment-resistant depression: definitions, pseudoresistance workup, evidence-based treatments including SPRAVATO monotherapy, SAINT, and a 10-step management algorithm. By Nefretiri Abat, PMHNP-BC, JD.

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Intrusive Thoughts and Brain Circuits: The Neuroscience of OCD (and How It’s Treated)

OCD isn’t a matter of willpower or personality — it’s a pattern in specific brain circuits, and understanding that pattern helps explain why the evidence-based treatments work. The loop behind the symptoms Researchers consistently implicate

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Psychedelic Microdosing vs TMS for Depression

Microdosing versus TMS for depression People with severe depression sometimes ask how psychedelic microdosing compares with TMS. The two are not equivalent. TMS is FDA-cleared for major depressive disorder. Psychedelic microdosing is not an approved

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