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Category: Treatment-Resistant Depression

My Family Member’s Depression Isn’t Getting Better. How Can I Help?

When someone you love is not improving on antidepressants, there are specific and useful things you can do. Here they are.

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My Antidepressant Stopped Working. What Now?

An antidepressant that worked and then stopped affects a substantial share of people. Here is why it happens and what to do next.

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Why Don’t Antidepressants Work for Me?

Antidepressants fail for specific reasons, and most of them are findable. Here are the six most common, and what to do about each.

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I’ve Tried Three Antidepressants and Nothing Works. What Are My Options?

If two or more antidepressants have not helped at an adequate dose and duration, that pattern has a clinical name and it narrows what to try next. A clinician walks through what to recheck first

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Does Medi-Cal Cover Spravato in California?

Medi-Cal covers Spravato for treatment-resistant depression through most managed care plans, with prior authorization and step therapy. See who qualifies and how coverage works.

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Can TMS and Spravato Be Used Together Without Overloading Treatment?

TMS and SPRAVATO work through different mechanisms, so combining them is possible — but more isn't automatically better. What safe combined or sequential use requires.

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If Spravato Didn’t Work, You May Need More Than Another Treatment

If SPRAVATO didn't work, the answer isn't always another treatment. What 'it didn't work' can actually mean, and the structured re-evaluation that should come next.

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What If TMS Doesn’t Work — or You Had to Stop Early?

If TMS didn't help, or you had to stop early, it isn't the end of the road. What a disappointing or interrupted TMS course means, and the next steps that may help.

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Spravato or TMS First: How Panic, Dissociation, and Schedule Change the Decision

When both TMS and SPRAVATO are on the table, the order often comes down to what you can tolerate. How panic, dissociation, and schedule shape the decision.

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Why Severe Anxiety and Depression Need More Than One Kind of Treatment

When anxiety and depression feed each other, one treatment is rarely enough. Why combined plans work better, and what they include.

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