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Category: Treatment-Resistant Depression

Sunlit writing desk with leather-bound notebook, fountain pen, and coffee — symbolizing the careful medication audit that defines a real treatment-resistant depression diagnosis. Exxceed Wellness, Hayward CA.
Ketamine therapy

How Treatment-Resistant Depression Is Diagnosed: The Two-Failed-Trials Standard, Explained

Nefretiri Abat, JD, PMHNP-BC0 Comments

A patient-facing clinical guide to the FDA/EMA two-failed-trials standard for diagnosing treatment-resistant depression — what counts as an adequate trial, why pseudoresistance must be ruled out first, and what comes next. By Nefretiri Abat, PMHNP-BC,

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Editorial photograph of a person in soft morning light, symbolizing the calm clarity of recovery from treatment-resistant depression — clinician's guide from Exxceed Wellness, Hayward CA
Ketamine therapy

What Is Treatment-Resistant Depression? A Clinician’s Guide to TRD

Nefretiri Abat, JD, PMHNP-BC0 Comments

A 2026 clinical guide to treatment-resistant depression: definitions, pseudoresistance workup, evidence-based treatments including SPRAVATO monotherapy, SAINT, and a 10-step management algorithm. By Nefretiri Abat, PMHNP-BC, JD.

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