Preparing for Your First Spravato Appointment

The first Spravato appointment takes about two hours. Patients self-administer the nasal spray in the clinic under supervision, then remain for approximately 90 minutes of monitoring. Driving afterward is not permitted, so a designated driver or rideshare is required on every treatment day, including the first.

During the visit:

• The nasal spray is self-administered in the clinic under the supervision of a REMS-certified provider.
• Blood pressure is checked before dosing and during the monitoring period.
• Dissociation, dizziness, drowsiness or nausea may occur and typically resolve before discharge.
• Discharge follows once the provider confirms the patient is medically stable.

To prepare:

• Arrange a designated driver or rideshare in advance. This is a REMS requirement, not a preference.
• Plan for a two-hour appointment.
• Keep the remainder of the day free of work, driving, childcare and other responsibilities.

Additional questions about Spravato are answered in our Spravato FAQ, or may be directed to (415) 636-9700, weekdays 8am to 8pm.