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Tag: treatment-resistant depression

Editorial still life of an olive sprig in a cream ceramic vessel beside a brass compass on navy linen — Exxceed Wellness blog hero for combining SPRAVATO and TMS in treatment-resistant depression.
Ketamine therapy

Can I Do SPRAVATO and TMS at the Same Time? A Treatment-Resistant Depression Specialist Answers

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For most patients with TRD, SPRAVATO and TMS can be combined or sequenced. Here's what the evidence says — and how we sequence at Exxceed Wellness.

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Editorial photograph of warm afternoon sunlight crossing through an arched doorway onto cream linen and oak floor — Exxceed Wellness blog hero for how Spravato esketamine works in the brain.
Ketamine therapy

Spravato (esketamine) explained: how it works in the brain

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Why Spravato (esketamine) acts in 24 hours when SSRIs take six to eight weeks — and why the dissociation patients fear is not the antidepressant. A patient-first walkthrough of the NMDA → AMPA → BDNF

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Sunlit writing desk with leather-bound notebook, fountain pen, and coffee — symbolizing the careful medication audit that defines a real treatment-resistant depression diagnosis. Exxceed Wellness, Hayward CA.
Ketamine therapy

How Treatment-Resistant Depression Is Diagnosed: The Two-Failed-Trials Standard, Explained

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A patient-facing clinical guide to the FDA/EMA two-failed-trials standard for diagnosing treatment-resistant depression — what counts as an adequate trial, why pseudoresistance must be ruled out first, and what comes next. By Nefretiri Abat, PMHNP-BC,

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Editorial photograph of a person in soft morning light, symbolizing the calm clarity of recovery from treatment-resistant depression — clinician's guide from Exxceed Wellness, Hayward CA
Ketamine therapy

What Is Treatment-Resistant Depression? A Clinician’s Guide to TRD

Exxceed Inc.0 Comments

A 2026 clinical guide to treatment-resistant depression: definitions, pseudoresistance workup, evidence-based treatments including SPRAVATO monotherapy, SAINT, and a 10-step management algorithm. By Nefretiri Abat, PMHNP-BC, JD.

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